[HTML][HTML] The role of berberine in Covid-19: potential adjunct therapy

AO Babalghith, HM Al-Kuraishy, AI Al-Gareeb… - …, 2022 - Springer
Abstract Coronavirus disease 2019 (Covid-19) is a global diastrophic disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Covid-19 leads to …

[HTML][HTML] Berberine: An inspiring resource for the treatment of colorectal diseases

F Cao, W Xia, S Dai, C Wang, R Shi, Y Yang… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer is a prevalent malignant tumor with a complex and diverse pathogenesis.
In recent years, natural products have shown promising application prospects as sources of …

Restorative effects of ethanolic leaf extract of Datura stramonium against methotrexate-induced hematological impairments

EU Alum, OPC Ugwu, PM Aja, EI Obeagu… - Cogent Food & …, 2023 - Taylor & Francis
One of the prominent complications observed in those undergoing treatment with
methotrexate (MTX) is hematological profile alterations which could culminate in severe …

Di-(2-Ethylhexyl) phthalate and microplastics induced neuronal apoptosis through the PI3K/AKT pathway and mitochondrial dysfunction

W Zhang, X Sun, X Qi, X Liu, Y Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Di-(2-Ethylhexyl) phthalate (DEHP) and microplastics (MPs) have released widespread
residues to the environment and possess the ability to cause damage to humans and …

Ethanolic leaf extract of Datura stramonium attenuates methotrexate-induced biochemical alterations in Wistar Albino rats

EU Alum, JE Inya, OPC Ugwu… - RPS Pharmacy and …, 2023 - academic.oup.com
Objectives Methotrexate (MTX) is a commonly used anti-cancer drug. However, its usage
could lead to various biochemical dysregulations culminating in organ toxicity. Globally …

[HTML][HTML] Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and …

EU Alum, AC Famurewa, OU Orji, PM Aja… - Avicenna Journal of …, 2023 - ncbi.nlm.nih.gov
Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in
different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical …

Buspirone attenuated methotrexate‐induced hippocampal toxicity in rats by regulating Nrf2/HO‐1, PPAR‐γ, NF‐κB/nNOS, and ROS/NLRP3/caspase‐1 signaling …

HS Althagafy, ZW Sharawi, AH Batawi… - … of Biochemical and …, 2023 - Wiley Online Library
Methotrexate (MTX) is a chemotherapeutic agent widely used to treat a variety of tumors.
Nonetheless, MTX‐induced hippocampal neurotoxicity is a well‐defined dose‐limiting …

The underlying mechanism of A‐type procyanidins from peanut skin on DSS‐induced ulcerative colitis mice by regulating gut microbiota and metabolism

B Huang, L Wang, M Liu, X Wu, Q Lu… - Journal of Food …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is a kind of inflammatory bowel disease. Procyanidins have been
found to prevent UC. However, most research has been focused on the alleviation effect of B …

Neodymium affects the generation of reactive oxygen species via GSK-3β/Nrf2 signaling in the gill of zebrafish

D Liu, X Wu, C Hu, Y Zeng, Q Pang - Aquatic Toxicology, 2023 - Elsevier
Rare earth element neodymium (Nd) is widely used in industry and agriculture, which may
result in the pollution of aquatic environment. In this study, we exposed zebrafish with 10, 50 …

Protective effects of berberine on various kidney diseases: emphasis on the promising effects and the underlined molecular mechanisms

EHM Hassanein, IM Ibrahim, EK Abd-Alhameed… - Life Sciences, 2022 - Elsevier
Berberine (BBR) is a pentacyclic benzylisoquinoline alkaloid that can be found in diversity of
medicinal plants. BBR has a wide range of pharmacological bioactivities, in addition when …