In this review, we describe the current state of knowledge about the biochemistry of
mammalian peroxisomes, especially human peroxisomes. The identification and …

Membrane proteins responsible for the active efflux of structurally and functionally unrelated
drugs were first characterized in higher eukaryotes. To date, a vast number of transporters …

Mapping protein–protein interactions is an invaluable tool for understanding protein
function. Here, we report the first large‐scale study of protein–protein interactions in human …

We describe the first complete inventory of ATP-binding cassette (ABC) proteins from a
multicellular organism, the model plant Arabidopsis thaliana. By the application of several …

Peroxisomes are important organelles in plant metabolism, containing all the enzymes
required for fatty acid β-oxidation. More than 20 proteins are required for peroxisomal …

Abstract X‐linked adrenoleukodystrophy (X‐ALD) is caused by mutations in the ABCD1
gene, which encodes a peroxisomal ABC half‐transporter (ALDP) involved in the import of …

Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an
autosomal recessive disorder of sterol trafficking. To determine the site of action of ABCG5 …

The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …

X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene
encoding a peroxisomal ABC transporter. In this review, we compare estimates of incidence …

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane
proteins, and are present in almost all living organisms from eubacteria to mammals. They …