Mechanisms and functions of nuclear envelope remodelling

R Ungricht, U Kutay - Nature Reviews molecular cell biology, 2017 - nature.com
As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Nucleolus and nuclear periphery: velcro for heterochromatin

J Padeken, P Heun - Current opinion in cell biology, 2014 - Elsevier
Heterochromatin was first defined by Emil Heitz in 1928 by light microscopy. In the 1950s
electron microscopy studies revealed that heterochromatin preferentially localizes to the …

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

HQ Le, S Ghatak, CYC Yeung, F Tellkamp… - Nature cell …, 2016 - nature.com
Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues

SJ Heo, S Thakur, X Chen, C Loebel, B Xia… - Nature biomedical …, 2023 - nature.com
Abstract Changes in the micro-environment of fibrous connective tissue can lead to
alterations in the phenotypes of tissue-resident cells, yet the underlying mechanisms are …

A-type lamins bind both hetero-and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

K Gesson, P Rescheneder, MP Skoruppa… - Genome …, 2016 - genome.cshlp.org
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic
genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being …

Nucleolar dynamics and interactions with nucleoplasm in living cells

CM Caragine, SC Haley, A Zidovska - Elife, 2019 - elifesciences.org
Liquid-liquid phase separation (LLPS) has been recognized as one of the key cellular
organizing principles and was shown to be responsible for formation of membrane-less …

Targeting DNA repair in cancer: current state and novel approaches

A Klinakis, D Karagiannis, T Rampias - Cellular and Molecular Life …, 2020 - Springer
DNA damage response, DNA repair and genomic instability have been under study for their
role in tumor initiation and progression for many years now. More recently, next-generation …

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

A Poleshko, CL Smith, SC Nguyen… - Elife, 2019 - elifesciences.org
Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It
remains unclear how essential positional information is transmitted through cell division …

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin

K Hiragami-Hamada, S Soeroes, M Nikolov… - Nature …, 2016 - nature.com
Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein
1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for …

Higher chromatin mobility supports totipotency and precedes pluripotency in vivo

A Bošković, A Eid, J Pontabry, T Ishiuchi… - Genes & …, 2014 - genesdev.cshlp.org
The fusion of the gametes upon fertilization results in the formation of a totipotent cell.
Embryonic chromatin is expected to be able to support a large degree of plasticity. However …