Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

Cortical spreading depression (CSD) and depolarization waves are associated with
dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells …

Laser Speckle Contrast Imaging (LSCI) is a wide field of view, non scanning optical
technique for observing blood flow. Speckles are produced when coherent light scattered …

Since its original extensive description by Leao in 1944, thousands of publications have
characterized the phenomenon of cortical spreading depression (CSD). Despite the …

How does infarction in victims of stroke and other types of acute brain injury expand to its
definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread …

Cortical spreading depression (CSD) is associated with a dramatic failure of brain ion
homeostasis and increased energy metabolism. There is strong clinical and experimental …

Here we investigated the incidence of cortical spreading depolarizations (spreading
depression and peri-infarct depolarization) after traumatic brain injury (TBI) and their …

Cortical spreading depolarizations occur spontaneously after ischaemic, haemorrhagic and
traumatic brain injury. Their effects vary spatially and temporally as graded phenomena …