Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …

Cell surface receptors control how cells respond to their environment. Many cell surface
receptors recycle from endosomes to the plasma membrane via a recently discovered …

Membranes are essential for cells and organelles to function. As membranes are
impermeable to most polar and charged molecules, they provide electrochemical energy to …

Objective—Class III phosphoinositide 3-kinase, also known as VPS34 (vacuolar protein
sorting 34), is a highly conserved enzyme regulating important cellular functions such as …

A single nucleotide polymorphism in Ncf1 has been found with a major effect on chronic
inflammatory autoimmune diseases in the rat with the surprising observation that a lower …

Legionella pneumophila and other Legionella species replicate intracellularly using the
Icm/Dot type IV secretion system. In L. pneumophila this system translocates> 300 effectors …

Following endocytosis, receptors that are internalized to sorting endosomes are sorted to
different pathways, in part by sorting nexin (SNX) proteins. Notably, SNX17 interacts with a …

The PDZ and LIM domain (PDLIM) proteins are associated with the actin cytoskeleton and
have conserved in roles in metazoan actin organisation and function. They primarily function …