Nuclear landscape of HIV-1 infection and integration
M Lusic, RF Siliciano - Nature Reviews Microbiology, 2017 - nature.com
To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
Understanding HIV latency: the road to an HIV cure
MS Dahabieh, E Battivelli, E Verdin - Annual review of medicine, 2015 - annualreviews.org
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …
individuals. However, treatment has to be continued for life because it does not lead to the …
Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
M Stremlau, CM Owens, MJ Perron, M Kiessling… - Nature, 2004 - nature.com
Host cell barriers to the early phase of immunodeficiency virus replication explain the current
distribution of these viruses among human and non-human primate species,,,. Human …
distribution of these viruses among human and non-human primate species,,,. Human …
[HTML][HTML] Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells
E Battivelli, MS Dahabieh, M Abdel-Mohsen… - Elife, 2018 - elifesciences.org
Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …
[HTML][HTML] HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
[HTML][HTML] SIRT1 regulates HIV transcription via Tat deacetylation
The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional
coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is …
coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is …
Discovery of small-molecule degraders of the CDK9-cyclin T1 complex for targeting transcriptional addiction in prostate cancer
Aberrant hyperactivation of cyclins results in carcinogenesis and therapy resistance in
cancers. Direct degradation of the specific cyclin or cyclin-dependent kinase (CDK)-cyclin …
cancers. Direct degradation of the specific cyclin or cyclin-dependent kinase (CDK)-cyclin …
[HTML][HTML] Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
L Colin, C Van Lint - Retrovirology, 2009 - Springer
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …
infected patients under HAART since interruption of the treatment inevitably leads to a …
[HTML][HTML] Regulation of HIV‐1 gene expression by histone acetylation and factor recruitment at the LTR promoter
In HIV‐1 infected cells, the LTR promoter, once organized into chromatin, is transcriptionally
inactive in the absence of stimulation. To examine the chromosomal events involved in …
inactive in the absence of stimulation. To examine the chromosomal events involved in …