Conservation of biodiversity in the genomics era
MA Supple, B Shapiro - Genome biology, 2018 - Springer
Abstract “Conservation genomics” encompasses the idea that genome-scale data will
improve the capacity of resource managers to protect species. Although genetic approaches …
improve the capacity of resource managers to protect species. Although genetic approaches …
Hybridization in plants: old ideas, new techniques
Hybridization has played an important role in the evolution of many lineages. With the
growing availability of genomic tools and advancements in genomic analyses, it is becoming …
growing availability of genomic tools and advancements in genomic analyses, it is becoming …
Efficient coalescent simulation and genealogical analysis for large sample sizes
J Kelleher, AM Etheridge… - PLoS computational …, 2016 - journals.plos.org
A central challenge in the analysis of genetic variation is to provide realistic genome
simulation across millions of samples. Present day coalescent simulations do not scale well …
simulation across millions of samples. Present day coalescent simulations do not scale well …
An overview of STRUCTURE: applications, parameter settings, and supporting software
L Porras-Hurtado, Y Ruiz, C Santos, C Phillips… - Frontiers in …, 2013 - frontiersin.org
Objectives: We present an up-to-date review of STRUCTURE software: one of the most
widely used population analysis tools that allows researchers to assess patterns of genetic …
widely used population analysis tools that allows researchers to assess patterns of genetic …
[HTML][HTML] Integrated analysis of genetic ancestry and genomic alterations across cancers
Disparities in cancer care have been a long-standing challenge. We estimated the genetic
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …
ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the …
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
SH Jiang, V Athanasopoulos, JI Ellyard… - Nature …, 2019 - nature.com
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is
thought that many common variant gene loci of weak effect act additively to predispose to …
thought that many common variant gene loci of weak effect act additively to predispose to …
A dispersal of Homo sapiens from southern to eastern Africa immediately preceded the out-of-Africa migration
Africa was the birth-place of Homo sapiens and has the earliest evidence for symbolic
behaviour and complex technologies. The best-attested early flowering of these distinctive …
behaviour and complex technologies. The best-attested early flowering of these distinctive …
Tracking crop varieties using genotyping-by-sequencing markers: a case study using cassava (Manihot esculenta Crantz)
IY Rabbi, PA Kulakow, JA Manu-Aduening, AA Dankyi… - BMC genetics, 2015 - Springer
Background Accurate identification of crop cultivars is crucial in assessing the impact of crop
improvement research outputs. Two commonly used identification approaches, elicitation of …
improvement research outputs. Two commonly used identification approaches, elicitation of …
Genetic ancestry analysis on> 93,000 individuals undergoing expanded carrier screening reveals limitations of ethnicity-based medical guidelines
Purpose Carrier status associates strongly with genetic ancestry, yet current carrier
screening guidelines recommend testing for a limited set of conditions based on a patient's …
screening guidelines recommend testing for a limited set of conditions based on a patient's …
A primer on the use of machine learning to distil knowledge from data in biological psychiatry
Applications of machine learning in the biomedical sciences are growing rapidly. This
growth has been spurred by diverse cross-institutional and interdisciplinary collaborations …
growth has been spurred by diverse cross-institutional and interdisciplinary collaborations …