The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

Hepatocyte nuclear factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent
studies have highlighted its role in inhibition of hepatocyte proliferation and tumor …

Although the signaling pathways involved in normal liver regeneration have been well
characterized, less has been done for livers affected by chronic tissue damage. These …

Background Heightened signaling by mesenchymal epithelial transition factor (MET) is
implicated in tumorigenesis. Glesatinib is an investigational, oral inhibitor of MET and AXL …

Epidermal growth factor receptor (EGFR) is conventionally known to play a crucial role in
hepatocyte proliferation, liver regeneration and is also associated with hepatocellular …

Chronic liver injury results in cirrhosis and end-stage liver disease (ESLD) which represents
a leading cause of death worldwide, affecting people in their most productive years of life …

The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …