A review of recent synthetic strategies and biological activities of isoxazole

CP Pandhurnekar, HC Pandhurnekar… - Journal of …, 2023 - Wiley Online Library
Among different heterocyclic compounds, isoxazole and their analogues are very important
classes of heterocyclic compounds as they display an extensive range of biological actions …

[HTML][HTML] An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold

S Das, K Chanda - RSC advances, 2021 - pubs.rsc.org
In the field of drug discovery, isoxazole is a five-membered heterocyclic moiety commonly
found in many commercially available drugs. In view of their enormous significance, it is …

[HTML][HTML] Synthesis of novel sulphamethoxazole derivatives and exploration of their anticancer and antimicrobial properties

R Vaickelionienė, V Petrikaitė, I Vaškevičienė… - Plos one, 2023 - journals.plos.org
A series of new derivatives based on sulfamethoxazole were designed and synthesized in
this study. The structures of the new compounds were confirmed based on a comprehensive …

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes

S Hofmann, J Winter, T Prenzel… - …, 2023 - Wiley Online Library
Isoxazol (in) es are widely featured structural motifs in natural products, agrochemicals, and
pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis …

Cytotoxic and apoptotic effects of some (R)-carvone-isoxazoline derivatives on human fibrosarcoma and carcinoma cells: experimental evaluation for cytotoxicity …

A Oubella, A Bimoussa, S Byadi… - Journal of …, 2023 - Taylor & Francis
This study aimed to analyze the cytotoxic and apoptotic effects of isoxazoline derivatives
with monoterpene scaffold 9a–e in HT-1080 fibrosarcoma, MCF-7, and MDA-MB-231 breast …

Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo [5, 4–d] pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents

NB Gaikwad, S Bansod, A Mara, R Garise… - Bioorganic & Medicinal …, 2021 - Elsevier
A library of new 3-phenylisoxazolo [5, 4–d] pyrimidines (8–10) was designed based on a
scaffold hybridization technique incorporating the important pharmacophoric features of 4 …

Microwave-assisted synthesis of (3, 5-disubstituted isoxazole)-linked benzimidazolone derivatives: DFT calculations and biological activities

S Ibrahim, A Ghabi, N Amiri, H Mtiraoui, M Hajji… - Monatshefte für Chemie …, 2021 - Springer
The present work describes the synthesis, characterization, and biological activities of a
novel series of isoxazole linked benzimidazolones. The structures of the target compounds …

Magnetically separable new Fe3O4@ AgZr2 (PO4) 3 nanocomposite catalyst for the synthesis of novel isoxazole/isoxazoline-linked 1, 2, 3-triazoles in water under …

L Mokhi, A Moussadik, M Driowya… - Journal of Molecular …, 2024 - Elsevier
In this work, we report a novel magnetically separable Fe 3 O 4@ AgZr 2 (PO 4) 3 as
heterogeneous nano-composite catalyst for the one-pot four-step cascade …

Synthesis, molecular docking studies of formononetin derivatives as potent Bax agonists for anticancer activity

WD Jia, X Bai, QQ Ma, M Bian, CM Bai, D Li… - Natural Product …, 2023 - Taylor & Francis
Formononetin as a Bax agonist exhibits anticancer effects. To identify novel Bax agonist, 18
new structurally modified formononetin derivatives were synthesised and their anticancer …

An Efficient Access to 3, 5‐Disubstituted Isoxazoles with Anthranilate Ester Moiety: Alkaloid Lappaconitine–Aryl Conjugates with an Isoxazole Linker

KP Cheremnykh, VA Savelyev… - Asian Journal of Organic …, 2021 - Wiley Online Library
Alkynones have gained great attention as useful building blocks in organic synthesis. They
have been emerged as key intermediates in the synthesis of various heterocycles. In the …