Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …

A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …

One of the most consistent epidemiological associations between diet and human disease
risk is the impact of red meat consumption (beef, pork, and lamb, particularly in processed …

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …

In human cells, the integrity of genetic information is constantly challenged by endogenous
and exogenous chemical agents that can induce DNA damage. To counteract the …

Over two centuries ago, Sir Percival Pott, a London surgeon, published a pioneering treatise
showing that soot exposure was the cause of high incidences of scrotal cancers occurring in …

Epidemiologic studies have reported an association between frequent consumption of well-
done cooked meats and prostate cancer risk. However, unambiguous physiochemical …

Epidemiological studies have linked aromatic amines (AAs) from tobacco smoke and some
occupational exposures with bladder cancer risk. Several epidemiological studies have also …

Epidemiological and mechanistic studies suggest that processed and red meat consumption
and tobacco smoking are associated with colorectal cancer (CRC) risk. Several classes of …

Long-term exposures to environmental toxicants and endogenous electrophiles are
causative factors for human diseases including cancer. DNA adducts reflect the internal …