Cellular sources of TSPO expression in healthy and diseased brain

E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Recent advances in photonanomedicines for enhanced cancer photodynamic therapy

JJ Hu, Q Lei, XZ Zhang - Progress in Materials Science, 2020 - Elsevier
Nowadays, photodynamic therapy (PDT) that employs photosensitizers (PSs) to generate
cytotoxic species under light irradiation for selective destruction of neoplastic lesions has …

Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

V Papadopoulos, M Baraldi, TR Guilarte… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely
distributed transmembrane protein that is located mainly in the outer mitochondrial …

Relevance of breast cancer cell lines as models for breast tumours: an update

M Lacroix, G Leclercq - Breast cancer research and treatment, 2004 - Springer
The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity

RB Banati, J Newcombe, RN Gunn, A Cagnin… - Brain, 2000 - academic.oup.com
This study identifies by microautoradiography activated microglia/macrophages as the main
cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active …

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

Enigma of the peripheral benzodiazepine receptor

M Gavish, I Bachman, R Shoukrun, Y Katz… - Pharmacological …, 1999 - ASPET
Benzodiazepines (BZs) 2 are used clinically as muscle relaxants, anticonvulsants,
anxiolytics, and sedativehypnotics. These effects are mediated primarily via the central BZ …

Regulation of hexokinase binding to VDAC

JG Pastorino, JB Hoek - Journal of bioenergetics and biomembranes, 2008 - Springer
Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by
interacting with the outer membrane voltage-dependent anion channel (VDAC). This …

[HTML][HTML] The mitochondrial voltage-dependent anion channel 1 in tumor cells

V Shoshan-Barmatz, D Ben-Hail, L Admoni… - … et Biophysica Acta (BBA …, 2015 - Elsevier
VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Peripheral benzodiazepine receptors and mitochondrial function

P Casellas, S Galiegue, AS Basile - Neurochemistry international, 2002 - Elsevier
For over 20 years, numerous investigations have focused on elucidating the function of the
peripheral benzodiazepine receptor (PBR). This relatively small protein (18kDa) arouses …