Behavioral, neurochemical and developmental effects of chronic oral methylphenidate: a review

D Senior, R Ahmed, E Arnavut, A Carvalho… - Journal of Personalized …, 2023 - mdpi.com
The majority of animal studies on methylphenidate (MP) use intraperitoneal (IP) injections,
subcutaneous (SC) injections, or the oral gavage route of administration. While all these …

Treatment with methylphenidate and the risk of fractures among children and young people: A systematic review and self‐controlled case series study

L Gao, KKC Man, M Fan, GMQ Ge… - British Journal of …, 2023 - Wiley Online Library
Aims Animal studies suggest that methylphenidate treatment for around 3 months may lead
to less mineralized and weaker appendicular bones. A systematic review was conducted to …

Attention‐deficit‐hyperactivity disorder increases risk of bone fracture: a population‐based cohort study

IC Chou, CC Lin, FC Sung… - Developmental Medicine & …, 2014 - Wiley Online Library
Aim Attention‐deficit‐hyperactivity disorder (ADHD) is a disorder that is associated with
accidental injuries. The aim of this study was to evaluate the relationship between ADHD …

Combined methylphenidate and fluoxetine treatment in adolescent rats significantly impairs weight gain with minimal effects on skeletal development

AA Chirokikh, SMZ Uddin, N Areikat, R Jones, E Duque… - Bone, 2023 - Elsevier
Methylphenidate (MP) is frequently prescribed to treat Attention-Deficit/Hyperactivity
Disorder (ADHD); however, many patients with ADHD experience depression and anxiety …

A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior

PK Thanos, LS Robison, J Steier, YF Hwang… - Pharmacology …, 2015 - Elsevier
Most animal studies using methylphenidate (MP) do not administer it the same way it is
administered clinically (orally), but rather by injection, resulting in an altered …

Chronic oral methylphenidate treatment increases microglial activation in rats

E Carias, J Hamilton, LS Robison, F Delis… - Journal of Neural …, 2018 - Springer
Methylphenidate (MP) is a widely prescribed psychostimulant used to treat attention deficit
hyperactivity disorder. Previously, we established a drinking paradigm to deliver MP to rats …

ADHD, stimulant medication use, and the risk of fracture: a systematic review and meta-analysis

SW Zhang, D Shen, Y Yan - Archives of Osteoporosis, 2021 - Springer
We performed a meta-analysis to quantify the relationships among a diagnosis of attention-
deficit/hyperactivity disorder (ADHD), the use of stimulant medication, and the risk of fracture …

Methylphenidate regulation of osteoclasts in a dose-and sex-dependent manner adversely affects skeletal mechanical integrity

SMZ Uddin, LS Robison, D Fricke, E Chernoff… - Scientific reports, 2018 - nature.com
Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with
clinically demonstrated detrimental effects on bone quality, potentially leading to early onset …

Recovery from behavior and developmental effects of chronic oral methylphenidate following an abstinence period

C Martin, D Fricke, A Vijayashanthar… - Pharmacology …, 2018 - Elsevier
Chronic oral methylphenidate (MP) exposure in rats is associated with numerous
developmental and behavioral consequences. The present study investigated the …

Lower risk of fractures under methylphenidate treatment for ADHD: A dose–response effect

H Schermann, R Gurel, R Ankory… - Journal of …, 2018 - Wiley Online Library
Methylphenidate (MP), a widely used and abused stimulant medication for ADHD,
negatively affects bone mass. However, previous epidemiological studies demonstrated that …