Behavioral, neurochemical and developmental effects of chronic oral methylphenidate: a review
D Senior, R Ahmed, E Arnavut, A Carvalho… - Journal of Personalized …, 2023 - mdpi.com
The majority of animal studies on methylphenidate (MP) use intraperitoneal (IP) injections,
subcutaneous (SC) injections, or the oral gavage route of administration. While all these …
subcutaneous (SC) injections, or the oral gavage route of administration. While all these …
Treatment with methylphenidate and the risk of fractures among children and young people: A systematic review and self‐controlled case series study
Aims Animal studies suggest that methylphenidate treatment for around 3 months may lead
to less mineralized and weaker appendicular bones. A systematic review was conducted to …
to less mineralized and weaker appendicular bones. A systematic review was conducted to …
Attention‐deficit‐hyperactivity disorder increases risk of bone fracture: a population‐based cohort study
IC Chou, CC Lin, FC Sung… - Developmental Medicine & …, 2014 - Wiley Online Library
Aim Attention‐deficit‐hyperactivity disorder (ADHD) is a disorder that is associated with
accidental injuries. The aim of this study was to evaluate the relationship between ADHD …
accidental injuries. The aim of this study was to evaluate the relationship between ADHD …
Combined methylphenidate and fluoxetine treatment in adolescent rats significantly impairs weight gain with minimal effects on skeletal development
AA Chirokikh, SMZ Uddin, N Areikat, R Jones, E Duque… - Bone, 2023 - Elsevier
Methylphenidate (MP) is frequently prescribed to treat Attention-Deficit/Hyperactivity
Disorder (ADHD); however, many patients with ADHD experience depression and anxiety …
Disorder (ADHD); however, many patients with ADHD experience depression and anxiety …
A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior
Most animal studies using methylphenidate (MP) do not administer it the same way it is
administered clinically (orally), but rather by injection, resulting in an altered …
administered clinically (orally), but rather by injection, resulting in an altered …
Chronic oral methylphenidate treatment increases microglial activation in rats
E Carias, J Hamilton, LS Robison, F Delis… - Journal of Neural …, 2018 - Springer
Methylphenidate (MP) is a widely prescribed psychostimulant used to treat attention deficit
hyperactivity disorder. Previously, we established a drinking paradigm to deliver MP to rats …
hyperactivity disorder. Previously, we established a drinking paradigm to deliver MP to rats …
ADHD, stimulant medication use, and the risk of fracture: a systematic review and meta-analysis
SW Zhang, D Shen, Y Yan - Archives of Osteoporosis, 2021 - Springer
We performed a meta-analysis to quantify the relationships among a diagnosis of attention-
deficit/hyperactivity disorder (ADHD), the use of stimulant medication, and the risk of fracture …
deficit/hyperactivity disorder (ADHD), the use of stimulant medication, and the risk of fracture …
Methylphenidate regulation of osteoclasts in a dose-and sex-dependent manner adversely affects skeletal mechanical integrity
SMZ Uddin, LS Robison, D Fricke, E Chernoff… - Scientific reports, 2018 - nature.com
Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with
clinically demonstrated detrimental effects on bone quality, potentially leading to early onset …
clinically demonstrated detrimental effects on bone quality, potentially leading to early onset …
Recovery from behavior and developmental effects of chronic oral methylphenidate following an abstinence period
C Martin, D Fricke, A Vijayashanthar… - Pharmacology …, 2018 - Elsevier
Chronic oral methylphenidate (MP) exposure in rats is associated with numerous
developmental and behavioral consequences. The present study investigated the …
developmental and behavioral consequences. The present study investigated the …
Lower risk of fractures under methylphenidate treatment for ADHD: A dose–response effect
H Schermann, R Gurel, R Ankory… - Journal of …, 2018 - Wiley Online Library
Methylphenidate (MP), a widely used and abused stimulant medication for ADHD,
negatively affects bone mass. However, previous epidemiological studies demonstrated that …
negatively affects bone mass. However, previous epidemiological studies demonstrated that …