Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Revisiting inflammation in bipolar disorder

GR Fries, C Walss-Bass, ME Bauer… - … Biochemistry and Behavior, 2019 - Elsevier
Bipolar disorder (BD) has been associated with immune changes, and yet their underlying
mechanisms are still not fully understood. Here, we review the current state of the field …

Neuroinflammation in mood disorders: role of regulatory immune cells

ME Bauer, AL Teixeira - Neuroimmunomodulation, 2021 - karger.com
Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with
increased plasma levels of pro-inflammatory mediators targeting all tissues including the …

Inflammation in Bipolar Disorder (BD): Identification of new therapeutic targets

AC Pereira, J Oliveira, S Silva, N Madeira… - Pharmacological …, 2021 - Elsevier
Bipolar disorder (BD) is a chronic and cyclic mental disorder, characterized by unusual
mood swings between mania/hypomania and depression, raising concern in both scientific …

Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications

GR Fries, MJ Zamzow, T Andrews, O Pink… - Neuroscience & …, 2020 - Elsevier
Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …

Astrocyte, a promising target for mood disorder interventions

X Zhou, Q Xiao, L Xie, F Yang, L Wang… - Frontiers in molecular …, 2019 - frontiersin.org
Mood disorders have multiple phenotypes and complex underlying biological mechanisms
and, as such, there are no effective therapeutic strategies. A review of recent work on the …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Nutrition-based interventions for mood disorders

LB Martins, JR Braga Tibães, M Sanches… - Expert review of …, 2021 - Taylor & Francis
ABSTRACT Introduction:'Nutritional Psychiatry'is an emerging area of research that has
great potential as an adjunctive tool for the prevention and treatment of diverse …

Pathways linking obesity to neuropsychiatric disorders

LB Martins, NM Monteze, C Calarge, AVM Ferreira… - Nutrition, 2019 - Elsevier
Obesity has been associated with cognitive and behavioral syndromes. Individuals who are
obese have higher risk for developing neuropsychiatric disorders such as depression and …

Brain-immune crosstalk in the treatment of major depressive disorder

I Branchi, S Poggini, L Capuron, F Benedetti… - European …, 2021 - Elsevier
A growing number of studies are pointing out the need for a conceptual shift from a brain-
centered to a body-inclusive approach in mental health research. In this perspective, the link …