Nonhomologous DNA end-joining for repair of DNA double-strand breaks

NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

DNA-PKcs: a multi-faceted player in DNA damage response

X Yue, C Bai, D Xie, T Ma, PK Zhou - Frontiers in genetics, 2020 - frontiersin.org
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …

Repair of DNA double-strand breaks by the nonhomologous end joining pathway

BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

[HTML][HTML] DNA double strand break repair via non-homologous end-joining

AJ Davis, DJ Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …

Very fast CRISPR on demand

Y Liu, R Zou, Y Nihongaki, S He, S Razavi, B Wu… - Biophysical Journal, 2020 - cell.com
CRISPR/Cas systems have enormous potential as tools for genome editing and for studying
DNA damage response through convenient RNA-guided genomic targeting. We developed …

DNA-PK: a dynamic enzyme in a versatile DSB repair pathway

AJ Davis, BPC Chen, DJ Chen - DNA repair, 2014 - Elsevier
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …

Regulation of DNA double-strand break repair pathway choice

M Shrivastav, LP De Haro, JA Nickoloff - Cell research, 2008 - nature.com
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

N Jette, SP Lees-Miller - Progress in biophysics and molecular biology, 2015 - Elsevier
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

BL Mahaney, K Meek, SP Lees-Miller - Biochemical Journal, 2009 - portlandpress.com
DNA DSBs (double-strand breaks) are considered the most cytotoxic type of DNA lesion.
They can be introduced by external sources such as IR (ionizing radiation), by …

[HTML][HTML] Structure of an activated DNA-PK and its implications for NHEJ

X Chen, X Xu, Y Chen, JC Cheung, H Wang, J Jiang… - Molecular cell, 2021 - cell.com
DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …