Nonhomologous DNA end-joining for repair of DNA double-strand breaks
NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
DNA-PKcs: a multi-faceted player in DNA damage response
X Yue, C Bai, D Xie, T Ma, PK Zhou - Frontiers in genetics, 2020 - frontiersin.org
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …
Repair of DNA double-strand breaks by the nonhomologous end joining pathway
BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …
[HTML][HTML] DNA double strand break repair via non-homologous end-joining
AJ Davis, DJ Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Very fast CRISPR on demand
CRISPR/Cas systems have enormous potential as tools for genome editing and for studying
DNA damage response through convenient RNA-guided genomic targeting. We developed …
DNA damage response through convenient RNA-guided genomic targeting. We developed …
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
Regulation of DNA double-strand break repair pathway choice
M Shrivastav, LP De Haro, JA Nickoloff - Cell research, 2008 - nature.com
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
N Jette, SP Lees-Miller - Progress in biophysics and molecular biology, 2015 - Elsevier
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
BL Mahaney, K Meek, SP Lees-Miller - Biochemical Journal, 2009 - portlandpress.com
DNA DSBs (double-strand breaks) are considered the most cytotoxic type of DNA lesion.
They can be introduced by external sources such as IR (ionizing radiation), by …
They can be introduced by external sources such as IR (ionizing radiation), by …
[HTML][HTML] Structure of an activated DNA-PK and its implications for NHEJ
DNA-dependent protein kinase (DNA-PK), like all phosphatidylinositol 3-kinase-related
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …
kinases (PIKKs), is composed of conserved FAT and kinase domains (FATKINs) along with …