Targeting Rac and Cdc42 GEFs in metastatic cancer

MDM Maldonado, JI Medina, L Velazquez… - Frontiers in cell and …, 2020 - frontiersin.org
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic

V Casado-Medrano, MJ Baker… - Biochemical Society …, 2018 - portlandpress.com
The family of Rho GTPases are involved in the dynamic control of cytoskeleton
reorganization and other fundamental cellular functions, including growth, motility, and …

[HTML][HTML] Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

A Floerchinger, KJ Murphy, SL Latham, SC Warren… - Cell Reports, 2021 - cell.com
Assessing drug response within live native tissue provides increased fidelity with regards to
optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital …

Identification of novel predictive factors for post surgical corneal haze

NR Kumar, P Khamar, R Shetty, A Sharma, N Shetty… - Scientific Reports, 2019 - nature.com
Molecular factors altered in corneas that develop haze post refractive surgery have been
described, but pre-existing factors that predispose clinically normal corneas to aberrant …

Exploring the classification of cancer cell lines from multiple omic views

X Yang, Y Wen, X Song, S He, X Bo - PeerJ, 2020 - peerj.com
Background Cancer classification is of great importance to understanding its pathogenesis,
making diagnosis and developing treatment. The accumulation of extensive omics data of …

[HTML][HTML] P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer

L Barrio-Real, C Lopez-Haber, V Casado-Medrano… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract Phosphatidylinositol-3, 4, 5-Trisphosphate Dependent Rac Exchange Factor 1 (P-
Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding …

P‐Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site

JD Marotti, KE Muller, LJ Tafe… - … Journal of Breast …, 2017 - Wiley Online Library
Background. Phosphatidylinositol‐3, 4, 5‐trisphosphate‐dependent Rac exchange factor 1
(P‐Rex1) has been implicated in cancer growth, metastasis, and response to …

The Rho guanine nucleotide exchange factor P-Rex1 as a potential drug target for cancer metastasis and inflammatory diseases

DY Richard - Pharmacological Research, 2020 - Elsevier
Abstract Phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3)-dependent Rac exchanger 1 (P-
Rex1) is a guanine nucleotide exchange factor (GEF) for Rac small GTPases and the Rac …

Integrative analysis of transcriptional profile reveals LINC00052 as a suppressor of breast cancer cell migration

JM Sanchez-Lopez, EA Mandujano-Tinoco… - Cancer …, 2021 - content.iospress.com
BACKGROUND: Long-non-coding RNAs, a class of transcripts with lengths> 200 nt, play
key roles in tumour progression. Previous reports revealed that LINC00052 (long intergenic …

[HTML][HTML] Multisite phosphorylation of P-Rex1 by protein kinase C

JC Montero, S Seoane, S García-Alonso, A Pandiella - Oncotarget, 2016 - ncbi.nlm.nih.gov
P-Rex proteins are guanine nucleotide exchange factors (GEFs) that act on the Rho/Rac
family of GTP binding proteins. The activity of P-Rex proteins is regulated by several …