Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza
The genus Oryza is a model system for the study of molecular evolution over time scales
ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the …
ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the …
Mechanisms of OCT4-SOX2 motif readout on nucleosomes
Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …
Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution
Being integral primary producers in diverse ecosystems, microalgal genomes could be
mined for ecological insights, but representative genome sequences are lacking for many …
mined for ecological insights, but representative genome sequences are lacking for many …
Phylogenomic re-assessment of the thermophilic genus Geobacillus
Geobacillus is a genus of Gram-positive, aerobic, spore-forming obligate thermophiles. The
descriptions and subsequent affiliations of the species in the genus have mostly been based …
descriptions and subsequent affiliations of the species in the genus have mostly been based …
Anchored phylogenomics, evolution and systematics of Elateridae: Are all bioluminescent Elateroidea derived click beetles?
Simple Summary In the era of phylogenomics, new molecular sequencing and
computational techniques can aid in resolving phylogenetic relationships that were …
computational techniques can aid in resolving phylogenetic relationships that were …
Phylogenetic and Phylogenomic Definition of Rhizopus Species
Phylogenomic approaches have the potential to improve confidence about the inter-
relationships of species in the order Mucorales within the fungal tree of life. Rhizopus …
relationships of species in the order Mucorales within the fungal tree of life. Rhizopus …
Mechanisms that ensure speed and fidelity in eukaryotic translation termination
Translation termination, which liberates a nascent polypeptide from the ribosome specifically
at stop codons, must occur accurately and rapidly. We established single-molecule …
at stop codons, must occur accurately and rapidly. We established single-molecule …
The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets
RN Beech, C Neveu - Parasitology, 2015 - cambridge.org
Pentameric ligand-gated ion-channels rapidly transduce synaptic neurotransmitter signals to
an electrical response in post-synaptic neuronal or muscle cells and control the …
an electrical response in post-synaptic neuronal or muscle cells and control the …
Site-directed mutagenesis of HgcA and HgcB reveals amino acid residues important for mercury methylation
Methylmercury is a potent neurotoxin that is produced by anaerobic microorganisms from
inorganic mercury by a recently discovered pathway. A two-gene cluster, consisting of hgcA …
inorganic mercury by a recently discovered pathway. A two-gene cluster, consisting of hgcA …