Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …

Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the
pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are …

The liver represents the third most frequent site of metastasis in patients with breast cancer.
We performed in vivo selection using 4T1 breast cancer cells to identify genes associated …

Bone metastatic disease is a late-stage event of many common cancers, such as those of
prostate and breast. It is incurable and causes severe morbidity. Tumor and bone interact in …

Purpose: Presence of pelvic lymph node metastases is the main prognostic factor in early-
stage cervical cancer patients, primarily treated with surgery. Aim of this study was to identify …

Treat ments for painful osseous metastases may not only diminish pain, but may also
improve quality of life and independence/mobility, and reduce skeletal morbidity, potential …

Bone is the most common metastatic site for breast cancer, and bone metastases can cause
pain as well as risk of pathological fractures. Emerging treatments for metastatic bone …

Colon cancer is a major cause of cancer-related death, with significantly increasing rates of
incidence worldwide. The current study was designed to evaluate the anti-carcinogenic …

Transforming growth factor-β (TGF-β) is a well-known cytokine that controls various
processes in normal physiology and disease context. Strong preclinical and clinical …

Introduction CT10 regulator of kinase (Crk) adaptor proteins (CrkI, CrkII and CrkL) play a role
in integrating signals for migration and invasion of highly malignant breast cancer cell lines …