Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever.
Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We …

Coat proteins play multiple roles in the life cycle of a membrane‐bound transport
intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an …

ULK1 and ULK2 are thought to be essential for initiating autophagy, and Ulk1/2-deficient
mice die perinatally of autophagy-related defects. Therefore, we used a conditional knockout …

Autophagosomes are double‐membrane vesicles generated during autophagy. Biogenesis
of the autophagosome requires membrane acquisition from intracellular compartments, the …

Secretion is the cellular process present in every organism that delivers soluble proteins and
cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the …

A tendency in cell biology is to divide and conquer. For example, decades of painstaking
work have led to an understanding of endoplasmic reticulum (ER) and Golgi structure …