This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception,
proprioception and vascular development. Piezo proteins are distinct from other ion …

The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers.
However, their structures and mechanogating mechanisms remain unknown. Here we …

Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor
sensing forces from the surrounding bilayer. The profound structural diversity in these …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals.
Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms …

In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular
carriers of an excitatory mechanically activated current found in many cells. This discovery …

The conversion of mechanical force to chemical signals is critical for many biological
processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …