The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …

The obesity epidemic has become a global public health crisis in recent years and is
continuing to worsen at an alarming rate. However, the pathophysiological mechanisms …

Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been
associated with metabolic benefits, yet results so far have been inconsistent. In this study …

Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell
destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of …

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …