Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory
diseases of the airways. They both cause airway narrowing and are increasing in incidence …

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …

Combined phylogenetic and chromosomal location studies suggest that the orphan receptor
RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a …

Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-
protein-coupled seven-span transmembrane receptors present on plasma membranes of …

The discovery and development of the bicyclam AMD3100—a chemokine receptor
antagonist—has highlighted the therapeutic potential of such compounds in HIV infection …

This study was undertaken to demonstrate the unique specificity of the chemokine receptor
CXCR4 antagonist AMD3100. Calcium flux assays with selected chemokine/cell …

The CXC ligand (CXCL) 12/CXC receptor (CXCR) 4 chemokine–receptor axis controls
hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory …

Blood neutrophil homeostasis is essential for successful host defense against invading
pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and …

The WHIM syndrome is a rare immunodeficiency disorder characterized by warts,
hypogammaglobulinemia, infections, and myelokathexis. Dominant heterozygous mutations …

Background Emerging evidence suggests that myeloid cells play a critical role in
glioblastoma (GBM) immunosuppression. Disappointing results of recent checkpoint …