Syndecans are type I transmembrane proteins having a core protein modified with
glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of …

In the animal kingdom, innate immunity is the first line of defense against invading
pathogens. The dangers of microbial and parasitic attacks are countered by similar …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological
processes. The ECM plays fundamental developmental and physiological roles in health …

In Drosophila, defense against foreign pathogens is mediated by an effective innate immune
system, the cellular arm of which is composed of circulating hemocytes that engulf bacteria …

Background As both larvae and adults, mosquitoes encounter a barrage of immune insults,
ranging from microbe-rich communities in larval habitats to ingested blood-borne pathogens …

The cellular immune response against parasitoid wasps in Drosophila involves the
activation, mobilization, proliferation and differentiation of different blood cell types. Here, we …

Leukemia involves different types of blood cancers, which lead to significant mortality and
morbidity. Murine models of leukemia have been instrumental in understanding the biology …

Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and
generates novel fragments with biological activities functionally distinct from those of the …

Background We studied the expression of sulphated glycosaminoglycans (GAGs) in coeliac
disease (CD) mucosa, as they are critical determinants of tissue volume, which increases in …