Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …

Cancer was recognized as a genetic disease at least four decades ago, with the realization
that the spontaneous mutation rate must increase early in tumorigenesis to account for the …

Abstract Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in
recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous …

It is generally assumed that the allocation and synthesis of total cellular resources in
microorganisms are uniquely determined by the growth conditions. Adaptation to a new …

Despite the identification of many genes and pathways involved in the persistence
phenomenon of bacteria, the relative importance of these genes in a single organism …

The primary mechanisms by which bacteria lose viability when deprived of thymine have
been elusive for over half a century. Early research focused on stalled replication forks and …

Simple Summary The woody breast myopathy in broiler chickens results in inferior quality
breast meat. The severity of woody breast can negatively impact consumers' acceptance …

DNA viruses and retroviruses need to consume large quantities of deoxynucleotides
(dNTPs) when replicating within infected cells. The human antiviral factor SAMHD1 takes …

SUMMARY The El Tor biotype of Vibrio cholerae is responsible for perpetuating the longest
cholera pandemic in recorded history (1961-current). The genomic islands VSP-1 and-2 are …

We define chromosomal replication complexity (CRC) as the ratio of the copy number of the
most replicated regions to that of unreplicated regions on the same chromosome. Although a …