Molecular docking methodology explores the behavior of small molecules in the binding site
of a target protein. As more protein structures are determined experimentally using X-ray …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

The genome-wide identification of pairs of interacting proteins is an important step in the
elucidation of cell regulatory mechanisms,. Much of our present knowledge derives from …

Computational prediction of the 3D structures of molecular interactions is a challenging
area, often requiring significant computational resources to produce structural predictions …

Protein–protein interactions form central elements of almost all cellular processes.
Knowledge of the structure of protein–protein complexes but also of the binding affinity is of …

Objective The HBV HBx regulatory protein is required for transcription from the covalently
closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both …

Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …

The majority of biological processes are mediated via protein–protein interactions.
Determination of residues participating in such interactions improves our understanding of …

Protein interactions play an important role in the discovery of protein functions and pathways
in biological processes. This is especially true in case of the diseases caused by the loss of …

The identification of crosslinks by mass spectrometry has recently been established as an
integral part of the hybrid structural analysis of protein complexes and networks. The …