Glutamate is the most abundant neurotransmitter of the central nervous system, as the
majority of neurons use glutamate as neurotransmitter. It is also well known that this …

The comorbidity of depression and addiction has become a serious public health issue, and
the relationship between these two disorders and their potential mechanisms has attracted …

Drug addiction remains a key biomedical challenge facing current neuroscience research. In
addition to neural mechanisms, the focus of the vast majority of studies to date, astrocytes …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

PTSD is highly comorbid with cocaine use disorder (CUD), and cocaine users with PTSD+
CUD are more resistant to treatment. Here we sought to develop a rat model of PTSD+ CUD …

The nucleus accumbens (NAc) is located in the ventromedial portion of the striatum and is
vital to valence-based predictions and motivated action. The neural architecture of the NAc …

Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic
glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction …

The aim of this study was to evaluate the effects of cannabidiol (CBD) on the behavioural
and gene expression changes in a new animal model of spontaneous cocaine withdrawal …

Medication-assisted treatments are unavailable to patients with cocaine use disorders.
Efforts to develop potential pharmacotherapies have led to the identification of a promising …

Impaired glutamate homeostasis is a key characteristic of the neurobiology of drug addiction
in rodent models and contributes to the vulnerability to relapse to drug seeking. Although …