The microcirculation is responsible for orchestrating adjustments in vascular tone to match
local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the …

Controlled generation of reactive oxygen species orchestrates numerous physiological
signaling events (Finkel, T.(2011) Signal transduction by reactive oxygen species. J. Cell …

Plants defend against pathogen attack by modulating auxin signaling and activating the
salicylic acid (SA) and jasmonic acid (JA) signaling pathways. SA and JA act …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for
protein folding, degradation, chaperone function, and the ER stress response. Our …

Targeted covalent inhibitors have emerged as a powerful approach in the drug discovery
pipeline. Key to this process is the identification of signaling pathways (or receptors) specific …

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible
post-translational modification that plays a crucial role in regulating protein function and is …

Benzoxaboroles have garnered much attention in recent years due to their diverse
applications in bio-sensing technology, material science, and therapeutic intervention. Part …

In lung vascular cells, mitochondria serve a canonical metabolic role, governing energy
homeostasis. In addition, mitochondria exist in dynamic networks, which serve noncanonical …

Rationale: Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells (VSMCs) by
oxidative stress and promotes VSMC proliferation. However, the role of extracellular CyPA …