The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Vascularization, the formation of new blood vessels, is an essential biological process. As
the vasculature is involved in various fundamental physiological phenomena and closely …

The primed microenvironment of future metastatic sites, called the pre‐metastatic niche, is a
prerequisite for overt metastasis. However, a mechanistic understanding of the contributions …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …

Obesity is associated with adipose inflammation, defined by macrophages encircling dead
adipocytes, as well as extracellular matrix (ECM) remodeling and increased risk of breast …

MXenes are the two-dimensional single-layer atomic nanosheets derived from MAX-phase
ceramics. Currently, 2D MXene nanomaterials are extensively studied owing to their …

The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and
to achieve this function it must continually adapt to varying tissue demands. Newly formed …

Tumors, unlike normal tissue, have vascular anomalies and create interstitial flow (IF), which
allows soluble substances from cancer cells to be transported directionally toward the tumor …

The formation of complete and well-functioning endothelium is critical for the success of
tissue-engineered vascular grafts yet remaining a fundamental challenge. Endothelium …

In vitro investigation of a glomerular filtration barrier (GFB) remains difficult because of the
inability to mimic its specialized structure, although various kidney diseases are …