Peptide-based coacervates in therapeutic applications

L Ma, X Fang, C Wang - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Coacervates are droplets formed by liquid‒liquid phase separation. An increasing number
of studies have reported that coacervates play an important role in living cells, such as in the …

Rational design of elastin-like polypeptide fusion proteins to tune self-assembly and properties of protein vesicles

Y Li, DR Dautel, MA Gray, ME McKenna… - Journal of Materials …, 2023 - pubs.rsc.org
Protein vesicles made from bioactive proteins have potential value in drug delivery,
biocatalysis, and as artificial cells. As the proteins are produced recombinantly, the ability to …

Application of thermoresponsive intrinsically disordered protein polymers in nanostructured and microstructured materials

B Wang, SS Patkar, KL Kiick - Macromolecular bioscience, 2021 - Wiley Online Library
Modulation of inter‐and intramolecular interactions between bioinspired designer molecules
can be harnessed for developing functional structures that mimic the complex hierarchical …

Controlled delivery of vancomycin from collagen-tethered peptide vehicles for the treatment of wound infections

J Hwang, H Huang, MO Sullivan… - Molecular …, 2023 - ACS Publications
Despite the great promise of antibiotic therapy in wound infections, antibiotic resistance
stemming from frequent dosing diminishes drug efficacy and contributes to recurrent …

A Library of Elastin-like Proteins with Tunable Matrix Ligands for In Vitro 3D Neural Cell Culture

RA Suhar, MS Huang, RS Navarro… - …, 2023 - ACS Publications
Hydrogels with encapsulated cells have widespread biomedical applications, both as tissue-
mimetic 3D cultures in vitro and as tissue-engineered therapies in vivo. Within these …

Investigating the Hydrogen Bond-Induced Self-Assembly of Polysulfamides Using Molecular Simulations and Experiments

Z Wu, JW Wu, Q Michaudel, A Jayaraman - Macromolecules, 2023 - ACS Publications
In this paper, we present a synergistic, experimental, and computational study of the self-
assembly of N, N′-disubstituted polysulfamides driven by hydrogen bonds (H-bonds) …

Laccase-mediated formation of hydrogels based on silk-elastin-like protein polymers with ultra-high molecular weight

S Wang, W Huang, Z Feng, X Tian, D Wang… - International Journal of …, 2023 - Elsevier
As artificial extracellular matrix-like materials, silk-elastin-like protein (SELP) hydrogels, with
excellent mechanical properties, high tunability, favorable biocompatibility, and controlled …

Controlled Release of Drugs from Extracellular Matrix-Derived Peptide-Based Nanovesicles through Tailored Noncovalent Interactions

H Huang, J Hwang, S Anilkumar, KL Kiick - Biomacromolecules, 2024 - ACS Publications
Elastin–collagen nanovesicles (ECnV) have emerged as a promising platform for drug
delivery due to their tunable physicochemical properties and biocompatibility. The potential …

Molecular modeling and simulation of polymer nanocomposites with nanorod fillers

S Lu, Z Wu, A Jayaraman - The Journal of Physical Chemistry B, 2021 - ACS Publications
We present a coarse-grained (CG) molecular dynamics (MD) simulation study of polymer
nanocomposites (PNCs) containing nanorods with homogeneous and patchy surface …

Flexible customization of the self‐assembling abilities of short elastin‐like peptide Fn analogs by substituting N‐terminal amino acids

K Suyama, M Shimizu, I Maeda, T Nose - Biopolymers, 2022 - Wiley Online Library
Elastin‐like peptides (ELPs) are thermoresponsive biopolymers inspired by the
characteristic repetitive sequences of natural elastin. As ELPs exhibit temperature …