The field of population genomics has grown rapidly in response to the recent advent of
affordable, large-scale sequencing technologies. As opposed to the situation during the …

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …

Abstract The JAX Diversity Outbred population is a new mouse resource derived from
partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As …

Recently diverged taxa may continue to exchange genes. A number of models of speciation
with gene flow propose that the frequency of gene exchange will be lower in genomic …

Meiotic recombination predominantly occurs at discrete genomic loci called recombination
hotspots, but the features defining these areas are still largely unknown (reviewed in refs) …

In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …

The loss of recombination between sex chromosomes has occurred repeatedly throughout
nature, with important implications for their subsequent evolution. Explanations for this …

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being
developed as a resource for mammalian systems genetics. Here we describe an experiment …

Detailed linkage and recombination rate maps are necessary to use the full potential of
genome sequencing and population genomic analyses. We used a custom collared …