The WD40 domain is one of the most abundant and interacting domains in the eukaryotic
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …

Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors,
and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs …

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest
due to its involvement in a large array of crucial biological processes. Some of these are …

Relocalization of proteins is a hallmark of the DNA damage response. We use high-
throughput microscopic screening of the yeast GFP fusion collection to develop a systems …

The metastasis of cancer cells is the main cause of death in patients with gastric cancer
(GC). Mounting evidence has demonstrated the vital importance of tumor-associated …

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors
of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can …

Neutrophil migration is a coordinated process that is altered at multiple stages during sepsis.
In combination with impaired neutrophil function, these alterations culminate in defective …

Pyroptosis, an inflammatory form of programmed cell death, has been implicated in
eliminating pathogenic infections. However, macrophage pyroptosis–related proteins from …