Despite significant advancements in the diagnosis and treatment of osteosarcoma to date,
overall survival has remained relatively constant for over 2 decades. The challenge in …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

For patients with osteosarcoma, the use of chemotherapy has improved survival from 11%
with surgical resection alone in the 1960s, to 70% by the mid-1980s. However, survival has …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …

BACKGROUND: This study evaluated the safety and feasibility of the addition of
pamidronate to chemotherapy for treatment of osteosarcoma. METHODS: The authors …

Bisphosphonates are the standard of care in the treatment of malignant bone diseases,
because of their ability to inhibit osteoclast-mediated bone destruction. We review here …

The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's
sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical …

Aberrant activation of the Wnt/β-catenin signaling pathway promotes osteosarcoma
tumorigenesis and metastasis. In this study, we tested the hypothesis that osteosarcoma …