[HTML][HTML] FBXW7 in cancer: what has been unraveled thus far?
The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in …
Recent insight into the role of FBXW7 as a tumor suppressor
K Yumimoto, KI Nakayama - Seminars in cancer biology, 2020 - Elsevier
FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
[HTML][HTML] Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression
Angiogenesis enhances cancer metastasis and progression, however, the roles of
transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc …
transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc …
[HTML][HTML] Tumor suppressor FBXW7 and its regulation of DNA damage response and repair
H Lan, Y Sun - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The proper DNA damage response (DDR) and repair are the central molecular mechanisms
for the maintenance of cellular homeostasis and genomic integrity. The abnormality in this …
for the maintenance of cellular homeostasis and genomic integrity. The abnormality in this …
Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma
K Wang, X Qu, S Liu, X Yang, F Bie, Y Wang… - Journal of cancer …, 2018 - Springer
Purpose F-box proteins, as components of the Skp1-Cullin 1-F-box protein (SCF) E3
ubiquitin ligase, can specifically bind to substrates and regulate multiple tumor behaviors …
ubiquitin ligase, can specifically bind to substrates and regulate multiple tumor behaviors …
AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression
ZNF322A is an oncogenic zinc-finger transcription factor. Our published results show that
ZNF322A positively regulates transcription of alpha-adducin (ADD1) and cyclin D1 (CCND1) …
ZNF322A positively regulates transcription of alpha-adducin (ADD1) and cyclin D1 (CCND1) …
Advances in the study of circadian genes in non-small cell lung cancer
H Zhang, R Liu, B Zhang, H Huo… - Integrative Cancer …, 2022 - journals.sagepub.com
Circadian genes regulate several physiological functions such as circadian rhythm and
metabolism and participate in the cytogenesis and progression of various malignancies. The …
metabolism and participate in the cytogenesis and progression of various malignancies. The …
[HTML][HTML] Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with mulitiomics profiling for cancer therapy
Y Jiang, S Ni, B Xiao, L Jia - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications
that determine whether functional proteins are degraded or activated/inactivated. To date,> …
that determine whether functional proteins are degraded or activated/inactivated. To date,> …
Downregulation of microRNA‐326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer
SH Huang, HC Hsieh, JM Shieh, WC Su… - BioFactors, 2024 - Wiley Online Library
Zinc finger protein ZNF322A is an oncogenic transcription factor. Overexpression of
ZNF322A activates pro‐metastasis, cancer stemness, and neo‐angiogenesis‐related genes …
ZNF322A activates pro‐metastasis, cancer stemness, and neo‐angiogenesis‐related genes …
[HTML][HTML] ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in …
CHY Cheung, CL Hsu, TY Lin, WT Chen… - Journal of biomedical …, 2020 - Springer
Background ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type
zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to …
zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to …