Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of
extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary …

TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's
disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that …

Targeting neuroinflammation via CD33 inhibition and/or TREM2 activation may have
important implications for neurodegeneration in Alzheimer's disease and may be an addition …

Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …

Triggering receptor expressed on myeloid cells 2 (TREM2) has been shown with a
neuroprotective function against inflammation and neuronal injury in Alzheimer's disease …