Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

TH Hutson, S Di Giovanni - Nature Reviews Neurology, 2019 - nature.com
Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

[HTML][HTML] Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing

SK Leung, AR Jeffries, I Castanho, BT Jordan, K Moore… - Cell reports, 2021 - cell.com
Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA
molecules from a single pre-mRNA with a prominent role in the development and function of …

Regulation of endoplasmic reticulum turnover by selective autophagy

A Khaminets, T Heinrich, M Mari, P Grumati… - Nature, 2015 - nature.com
The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling
protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins …

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

P Grumati, G Morozzi, S Hölper, M Mari, MLIE Harwardt… - elife, 2017 - elifesciences.org
The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its
distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Form follows function: the importance of endoplasmic reticulum shape

LM Westrate, JE Lee, WA Prinz… - Annual review of …, 2015 - annualreviews.org
The endoplasmic reticulum (ER) has a remarkably complex structure, composed of a single
bilayer that forms the nuclear envelope, along with a network of sheets and dynamic tubules …