Developmental Control of Cell Cycle and Signaling

S Di Talia - Cold Spring Harbor Perspectives in Biology, 2024 - cshperspectives.cshlp.org
In most species, the earliest stages of embryogenesis are characterized by rapid
proliferation, which must be tightly controlled with other cellular processes across the large …

Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket

S Donoughe, J Hoffmann, T Nakamura… - Nature …, 2022 - nature.com
The blastoderm is a broadly conserved stage of early animal development, wherein cells
form a layer at the embryo's periphery. The cellular behaviors underlying blastoderm …

A geometric-tension-dynamics model of epithelial convergent extension

NH Claussen, F Brauns, BI Shraiman - Proceedings of the National …, 2024 - pnas.org
Convergent extension of epithelial tissue is a key motif of animal morphogenesis. On a
coarse scale, cell motion resembles laminar fluid flow; yet in contrast to a fluid, epithelial …

Aster repulsion drives short-ranged ordering in the Drosophila syncytial blastoderm

J De-Carvalho, S Tlili, L Hufnagel… - …, 2022 - journals.biologists.com
Biological systems are highly complex, yet notably ordered structures can emerge. During
syncytial stage development of the Drosophila melanogaster embryo, nuclei synchronously …

A nuclear jamming transition in vertebrate organogenesis

S Kim, R Amini, ST Yen, P Pospíšil, A Boutillon… - Nature Materials, 2024 - nature.com
Jamming of cell collectives and associated rigidity transitions have been shown to play a key
role in tissue dynamics, structure and morphogenesis. Cellular jamming is controlled by …

Temporal integration of inductive cues on the way to gastrulation

S McFann, S Dutta, JE Toettcher… - Proceedings of the …, 2021 - National Acad Sciences
Markers for the endoderm and mesoderm germ layers are commonly expressed together in
the early embryo, potentially reflecting cells' ability to explore potential fates before fully …

Finding the last bits of positional information

L McGough, H Casademunt, M Nikolić, Z Aridor… - PRX Life, 2024 - APS
In a developing embryo, information about the position of cells is encoded in the
concentrations of morphogen molecules. In the fruit fly, the local concentrations of just a …

Emergence and melting of active vortex crystals

M James, DA Suchla, J Dunkel, M Wilczek - Nature communications, 2021 - nature.com
Melting of two-dimensional (2D) equilibrium crystals is a complex phenomenon
characterized by the sequential loss of positional and orientational order. In contrast to …

The design and logic of terminal patterning in Drosophila

CM Smits, SY Shvartsman - Current topics in developmental biology, 2020 - Elsevier
Terminal regions of the early Drosophila embryo are patterned by the highly conserved ERK
cascade, giving rise to the nonsegmented terminal structures of the future larva. In less than …

Enucleation of the C. elegans embryo revealed dynein-dependent spacing between microtubule asters

K Fujii, T Kondo, A Kimura - Life Science Alliance, 2024 - life-science-alliance.org
The intracellular positioning of the centrosome, a major microtubule-organizing center, is
important for cellular functions. One of the features of centrosome positioning is the spacing …