The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
[HTML][HTML] RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
[HTML][HTML] Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
[HTML][HTML] Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
[HTML][HTML] m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer
B Zhang, Q Wu, B Li, D Wang, L Wang, YL Zhou - Molecular cancer, 2020 - Springer
Background The epigenetic regulation of immune response has been demonstrated in
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) …
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Z Shulman, N Stern-Ginossar - Nature immunology, 2020 - nature.com
Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …
m6A modification controls the innate immune response to infection by targeting type I interferons
Abstract N6-methyladenosine (m6A) is the most common mRNA modification. Recent
studies have revealed that depletion of m6A machinery leads to alterations in the …
studies have revealed that depletion of m6A machinery leads to alterations in the …
[HTML][HTML] NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Y Hu, C Chen, X Tong, S Chen, X Hu, B Pan… - Cell death & …, 2021 - nature.com
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
regulation of cell proliferation and metastasis formation and is upregulated in multiple …
[HTML][HTML] The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
M Cheng, L Sheng, Q Gao, Q Xiong, H Zhang, M Wu… - Oncogene, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant modification in eukaryotic
messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its …
messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its …