With the detailed description and analysis of several inhibitory receptor systems on lymphoid
and myeloid cells, a central paradigm has emerged in which the pairing of activation and …

All cells continually survey their environment and make decisions based on cues
encountered. This requires specific receptors that detect such cues, then transduce signals …

CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized
over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston …

Receptors carrying immunoreceptor tyrosine‐based inhibition motifs (ITIMs) in their
cytoplasmic tail control a vast array of cellular responses, ranging from autoimmunity …

Semaphorins are newcomers to the growing panoply of immunoregulatory proteins.
Members of this family were originally identified as proteins that provide axonal guidance …

We have identified the lymphocyte semaphorin CD100/Sema4D as a CD40-inducible
molecule by subtractive cDNA cloning. CD100 stimulation significantly enhanced the effects …

The critical role for the SH2 domain-containing SHP-1 tyrosine phosphatase in regulating
haemopoietic cell behaviour was initially revealed by data linking SHP-1 deficiency to the …

It is now well established that the members of the PTP (protein tyrosine phosphatase)
superfamily play critical roles in fundamental biological processes. Although there has been …

The class IV semaphorin CD100/Sema4D differentially utilizes two distinct receptors: plexin-
B1 in nonlymphoid tissues, such as brain and kidney, and CD72 in lymphoid tissues. We …

High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1
gene by promoter methylation was detected in various kinds of leukemias and lymphomas …