Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

The maternal immune response is essential for successful pregnancy, promoting immune
tolerance to the fetus while maintaining innate and adaptive immunity. Uncontrolled …

Lactoferrin (Lf), a cationic glycoprotein able to chelate two ferric irons per molecule, is
synthesized by exocrine glands and neutrophils. Since the first anti-microbial function …

Problem Inappropriate activation of the immune system, particularly the imbalance of T‐
helper type 17 (Th17)/regulatory T (Treg) cells is thought to play considerable roles in …

Although preeclampsia causes high maternal/fetal morbidity and mortality, the etiology of
this multi-system disorder still remains to be elucidated. Herein, we have characterized the …

Background Preeclampsia (PE), a serious and variable pregnancy complication affecting
5%–10% of the obstetric population, has an undetermined etiology, yet inflammation is …

Objective: Acute atherosis is characterized by subendothelial lipid-filled foam cells, fibrinoid
necrosis and perivascular lymphocytic infiltration. This lesion is generally confined to non …

Background Pre-eclampsia (PE) is a pregnancy complication associated with maternal and
fetal morbidity and mortality. Among the potential pathogenesis discussed, inflammation is …

Among several interleukin (IL)-6 family members, only IL-6 and IL-11 require a gp130
protein homodimer for intracellular signaling due to lack of intracellular signaling domain in …

Background Abnormalities of blood cell counts and of cytokine profiles in women with
hypertensive disorders of pregnancy (HDP) have been reported in several studies. Although …