Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate
Cells derived from pluripotent sources in vitro must resemble those found in vivo as closely
as possible at both transcriptional and functional levels in order to be a useful tool for …
as possible at both transcriptional and functional levels in order to be a useful tool for …
Human induced pluripotent stem cell-derived brain endothelial cells: current controversies
Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for
many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis …
many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis …
Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule
Angiogenesis plays an essential role in embryonic development, organ remodeling, wound
healing, and is also associated with many human diseases. The process of angiogenesis in …
healing, and is also associated with many human diseases. The process of angiogenesis in …
Comparative studies between the murine immortalized brain endothelial cell line (bEnd. 3) and induced pluripotent stem cell-derived human brain endothelial cells for …
J Sun, W Ou, D Han, A Paganini-Hill, MJ Fisher… - PLoS …, 2022 - journals.plos.org
Brain microvascular endothelial cells, forming the anatomical site of the blood-brain barrier
(BBB), are widely used as in vitro complements to in vivo BBB studies. Among the …
(BBB), are widely used as in vitro complements to in vivo BBB studies. Among the …
[HTML][HTML] Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor …
M Piantino, F Louis, Y Shigemoto-Mogami… - Materials Today Bio, 2022 - Elsevier
The blood-brain barrier (BBB), a selective barrier formed by brain microvascular endothelial
cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical …
cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical …
Engineering the human blood–brain barrier at the capillary scale using a double‐templating technique
In vitro blood–brain barrier (BBB) models have played an important role in studying
processes such as immune cell trafficking and drug delivery, as well as contributing to the …
processes such as immune cell trafficking and drug delivery, as well as contributing to the …
Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models
Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and
is derived from perturbations to normal cell processes by aging or environmental factors …
is derived from perturbations to normal cell processes by aging or environmental factors …
A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer
Metastatic brain cancer has poor prognosis due to challenges in both detection and
treatment. One contributor to poor prognosis is the blood–brain barrier (BBB), which …
treatment. One contributor to poor prognosis is the blood–brain barrier (BBB), which …
Differentiation of human iPS cells into sensory neurons exhibits developmental stage-specific cryopreservation challenges
R Li, P Walsh, V Truong, A Petersen… - Frontiers in Cell and …, 2021 - frontiersin.org
Differentiation of human induced pluripotent stem cells (hiPSCs) generates cell phenotypes
valuable for cell therapy and personalized medicine. Successful translation of these hiPSC …
valuable for cell therapy and personalized medicine. Successful translation of these hiPSC …
Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington's disease
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion
of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal …
of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal …