The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …

Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …

Multipotent stem cells and their lineage-restricted progeny drive nephron formation within
the developing kidney. Here, we document expression of the adult stem cell marker Lgr5 in …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Mammalian organs, including the lung and kidney, often adopt a branched structure to
achieve high efficiency and capacity of their physiological functions. Formation of a …

Abnormalities of kidney and urinary tract development are the most common cause of end-
stage kidney failure in childhood in the United States. Over the past 20 years, the advent of …

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …