[HTML][HTML] Collagenases and their inhibitors: a review

S Wu, X Zhou, Z Jin, H Cheng - Collagen and Leather, 2023 - Springer
Hide and skin are complex tissue where the most abundant component is collagen. Matrix
metalloproteinases and bacterial collagenases are two kinds of collagenases that can …

[HTML][HTML] Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis

Y Wang, P Wang, HY Cao, HT Ding, HN Su… - Nature …, 2022 - nature.com
The collagenases of Vibrio species, many of which are pathogens, have been regarded as
an important virulence factor. However, there is little information on the structure and …

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase‐1

SO Waheed, A Varghese, I DiCastri, B Kaski… - …, 2023 - Wiley Online Library
Abstract Metalloproteinase‐1 (MMP‐1) catalyzed collagen degradation is essential for a
wide variety of normal physiological processes, while at the same time contributing to …

[HTML][HTML] Molecular Dynamics Simulations of Matrix Metalloproteinase 13 and the Analysis of the Specificity Loop and the S1′− Site

JY Choi, E Chung - International Journal of Molecular Sciences, 2023 - mdpi.com
The specificity loop of Matrix Metalloproteinases (MMPs) is known to regulate recognition of
their substrates, and the S1′− site surrounded by the loop is a unique place to address the …

Virtual screening reveals fluorescent probes for detecting Pan-Zinc center activity in serum MMPs: A potential biomarker for early tumor screening

S Ju, Y Xiang, Y Xie, L Zuo, J Li, X Li, Y Wang… - Chemical Engineering …, 2024 - Elsevier
Early tumor screening is pivotal for enhancing tumor treatment efficacy and patient survival
rates, yet identifying reliable biomarkers for early detection remains a challenge. Previous …

Novel Insights into the Catalytic Mechanism of Collagenolysis by Zn (II)-Dependent Matrix Metalloproteinase-1

KR Gorantla, A Krishnan, SO Waheed, A Varghese… - Biochemistry, 2024 - ACS Publications
Collagen hydrolysis, catalyzed by Zn (II)-dependent matrix metalloproteinases (MMPs), is a
critical physiological process. Despite previous computational investigations into the …

Effects of the Nature of Metal Ion, Protein and Substrate on the Catalytic Center in Matrix Metalloproteinase‐1: Insights from Multilevel MD, QM/MM and QM Studies

A Varghese, SS Chaturvedi, B DiCastri… - …, 2022 - Wiley Online Library
Abstract Matrix metalloproteinase‐1 (MMP‐1) is a Zn (II) dependent endopeptidase involved
in the degradation of collagen, the most abundant structural protein in the extracellular …

[HTML][HTML] Optimized Recombinant Expression and Characterization of Collagenase in Bacillus subtilis WB600

Y Zhu, L Wang, K Zheng, P Liu, W Li, J Lin, W Liu… - Fermentation, 2022 - mdpi.com
Background: The collagenase encoding gene col was cloned into a pP43NMK vector and
amplified in Escherichia coli JM109 cells. The shuttle vector pP43NMK was used to sub …

Life is an integrated body of matter and spirit

WY Tong - 2023 - osf.io
In order to find the logical basis that human beings should live in harmony, or at least should
not intentionally hurt each other, we redefine several basic terms, such as matter and spirit …

Regulation of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Abdominal Aortic Aneurysm

S Wang, D Liu, X Zhang, X Tian - Cardiology Discovery, 2023 - mednexus.org
Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by destruction
and progressive expansion of the abdominal aortic wall. An AAA is typically defined as an …