Hepatitis E virus: advances and challenges

I Nimgaonkar, Q Ding, RE Schwartz… - Nature Reviews …, 2018 - nature.com
At least 20 million hepatitis E virus (HEV) infections occur annually, with> 3 million
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …

Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis

L Lu, C Li, CH Hagedorn - Reviews in medical virology, 2006 - Wiley Online Library
Nucleotide sequences from a total of 421 HEV isolates were retrieved from Genbank and
analysed. Phylogenetically, HEV was classified into four major genotypes. Genotype 1 was …

Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in Northern Uganda

EH Teshale, SP Grytdal, C Howard… - Clinical infectious …, 2010 - academic.oup.com
Background Outbreaks of infection with hepatitis E virus (HEV) are frequently attributed to
contaminated drinking water, even if direct evidence for this is lacking. Methods We …

Hepatitis E virus

SK Panda, D Thakral, S Rehman - Reviews in medical virology, 2007 - Wiley Online Library
Hepatitis E virus (HEV) is the aetiological agent of non‐HAV enterically transmitted hepatitis.
It is the major cause of sporadic as well as epidemic hepatitis, which is no longer confined to …

Characterization of a prototype strain of hepatitis E virus.

SA Tsarev, SU Emerson, GR Reyes… - Proceedings of the …, 1992 - National Acad Sciences
A strain of hepatitis E virus (SAR-55) implicated in an epidemic of enterically transmitted non-
A, non-B hepatitis, now called hepatitis E, was characterized extensively. Six cynomolgus …

The global burden of hepatitis E outbreaks: a systematic review

MS Hakim, W Wang, WM Bramer, J Geng… - Liver …, 2017 - Wiley Online Library
Hepatitis E virus (HEV) is responsible for repeated water‐borne outbreaks since the past
century, representing an emerging issue in public health. However, the global burden of …

High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan

D Boccia, JP Guthmann, H Klovstad… - Clinical infectious …, 2006 - academic.oup.com
Abstract Background. Hepatitis E virus (HEV) causes acute onset of jaundice and a high
case-fatality ratio in pregnant women. We provide a clinical description of hospitalized case …

[HTML][HTML] Hepatitis E epidemic, Uganda

EH Teshale, CM Howard, SP Grytdal… - Emerging infectious …, 2010 - ncbi.nlm.nih.gov
In October 2007, an epidemic of hepatitis E was suspected in Kitgum District of northern
Uganda where no previous epidemics had been documented. This outbreak has …

[HTML][HTML] Cell culture systems for the study of hepatitis E virus

TL Meister, J Bruening, D Todt, E Steinmann - Antiviral research, 2019 - Elsevier
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading
cause of enterically-transmitted viral hepatitis worldwide. Increasing numbers of HEV …

Epidemic hepatitis E in Pakistan: patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease

JP Bryan, SA Tsarev, M Iqbal, J Ticehurst… - Journal of Infectious …, 1994 - academic.oup.com
IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a
hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM …