Mechanism of action of atypical antipsychotic drugs in mood disorders

D Grinchii, E Dremencov - International Journal of Molecular Sciences, 2020 - mdpi.com
Atypical antipsychotic drugs were introduced in the early 1990s. Unlike typical
antipsychotics, which are effective only against positive symptoms of schizophrenia, atypical …

A focused review of the metabolic side-effects of clozapine

JWY Yuen, DD Kim, RM Procyshyn… - Frontiers in …, 2021 - frontiersin.org
The second generation antipsychotic drug clozapine represents the most effective
pharmacotherapy for treatment-resistant psychosis. It is also associated with low rates of …

Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them

AJ Al Omran, AS Shao, S Watanabe, Z Zhang… - Journal of …, 2022 - Springer
Background Anxiety disorders are the most prevalent mental illnesses in the US and are
estimated to consume one-third of the country's mental health treatment cost. Although …

Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders

R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Role and clinical implications of atypical antipsychotics in anxiety disorders, obsessive-compulsive disorder, trauma-related, and somatic symptom disorders: a …

U Albert, C Carmassi, F Cosci, D De Cori… - International Clinical …, 2016 - journals.lww.com
Atypical antipsychotics (AAs) may play a role in the treatment of anxiety disorders, obsessive-
compulsive disorder (OCD), and trauma-related disorders. No reviews on their differential …

Agomelatine for the treatment of generalized anxiety disorder

M Buoli, S Grassi, M Serati… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Agomelatine is a melatonergic antidepressant, approved for the treatment of
Major Depressive Disorder (MDD) in Europe and Australia, but not in the United States. This …

A role for oxytocin in the etiology and treatment of schizophrenia

ME Rich, HK Caldwell - Frontiers in endocrinology, 2015 - frontiersin.org
Schizophrenia is a chronic debilitating neuropsychiatric disorder estimated to affect 51
million people worldwide. Several symptom domains characterize schizophrenia, including …

Treatment–resistant panic disorder: a systematic review

RC Freire, MM Zugliani, RF Garcia… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: The prevalence of panic disorder (PD) in the population is high and these
patients have work impairment, high unemployment rates, seek medical treatment more …

Differential effects of acute treatment with antipsychotic drugs on peripheral catecholamines

HN Boyda, AA Ho, L Tse, RM Procyshyn… - Frontiers in …, 2020 - frontiersin.org
Antipsychotic drugs represent the most effective treatment for chronic psychotic disorders.
The newer second generation drugs offer the advantage of fewer neurological side-effects …

Evaluation of long-acting injectable antipsychotics with the corresponding oral formulation in a cohort of patients with schizophrenia: a real-world study in Spain

JA García-Carmona, J Simal-Aguado… - International Clinical …, 2021 - journals.lww.com
To date, only a few studies compared some long-acting injectables (LAIs) antipsychotics
showing similar symptom improvement, relapse rates and adherence to treatment. We …