The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Abnormal behavior of α-synuclein and prion proteins is the hallmark of Parkinson's disease
(PD) and prion illnesses, respectively, being complex neurological disorders. A primary …

Increasing evidence suggests a potential role for infectious pathogens in the etiology of
synucleinopathies, a group of age-related neurodegenerative disorders including …

The gut-brain axis is an essential communication pathway between the central nervous
system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse …

Unhealthy aging causes the development of various diseases, which makes intervening in
key targets an important breakthrough in the development of new drugs to delay aging and …

Parkinson's disease (PD) is a common neurodegenerative disease with complex
pathogenesis and no effective treatment. Recent studies have shown that dysbiosis of the …

Oxidation of succinate by mitochondria can generate a higher protonmotive force (pmf) than
can oxidation of NADH-linked substrates. Fundamentally, this is because of differences in …

Alterations of the microbiota-gut-brain axis has been associated with intestinal and neuronal
inflammation in Parkinson's disease (PD). The aim of this work was to study some …

The human gut microbiome is well‐recognized as a key player in maintaining health.
However, it is a dynamic entity that changes across the lifespan. How the microbial changes …

Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse
physiological processes that decline with age. Gut to brain vagus firing patterns are …