ALS genetics, mechanisms, and therapeutics: where are we now?
The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
Genome-wide analyses identify KIF5A as a novel ALS gene
To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
ESPEN guideline clinical nutrition in neurology
Neurological diseases are frequently associated with swallowing disorders and malnutrition.
Moreover, patients with neurological diseases are at increased risk of micronutrient …
Moreover, patients with neurological diseases are at increased risk of micronutrient …
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
HJ Westeneng, TPA Debray, AE Visser… - The Lancet …, 2018 - thelancet.com
Background Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor
neuron disease with a variable natural history. There are no accurate models that predict the …
neuron disease with a variable natural history. There are no accurate models that predict the …
Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
Although amyotrophic lateral sclerosis (ALS) is relatively rare, the socioeconomic
significance of the disease is extensive. It is therefore vital to project the epidemiologic trend …
significance of the disease is extensive. It is therefore vital to project the epidemiologic trend …
The protective role of exercise against age-related neurodegeneration
A Sujkowski, L Hong, RJ Wessells, SV Todi - Ageing Research Reviews, 2022 - Elsevier
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …
multiple organ systems. Exercise improves multiple indices of physical performance and …
The epidemiology of ALS: a conspiracy of genes, environment and time
A Al-Chalabi, O Hardiman - Nature Reviews Neurology, 2013 - nature.com
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …
of motor neurons, resulting in worsening weakness of voluntary muscles until death from …
Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature
Background: Amyotrophic lateral sclerosis (ALS) is relatively rare, yet the economic and
social burden is substantial. Having accurate incidence and prevalence estimates would …
social burden is substantial. Having accurate incidence and prevalence estimates would …