Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Computational trajectory inference enables the reconstruction of cell state dynamics from
single-cell RNA sequencing experiments. However, trajectory inference requires that the …

Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To …

Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of
extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the …

Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing
the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of …

In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including
the α-, β-, δ-, and pancreatic polypeptide cells as well as the exocrine cells, derive from …

Abstract Development of endocrine cells in the endoderm involves Atonal and
Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as …

The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms
controlling the differentiation of these cell types are largely unknown. Despite their …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …