Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance
phenotype is associated with the overexpression of the adenosine triphosphate (ATP) …

Aging is associated with reduced fitness and increased myeloid bias of the hematopoietic
stem cell (HSC) compartment, causing increased risk of immune compromise, anemia, and …

IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of
autoimmune inflammation. However, not all Th17 cells are pro-inflammatory. Pathogenic …

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Hematopoietic stem cells (HSC) are multipotent cells that reside in the bone marrow and
replenish all adult hematopoietic lineages throughout the lifetime of the animal. While …

Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified
by the'side-population'(SP) phenotype. Although it has been assumed that expression of …

▪ Abstract Considerable evidence has accumulated indicating that the multidrug transporter
or P-glycoprotein plays a role in the development of simultaneous resistance to multiple …