Investigation on the binding behavior of human α1-acid glycoprotein with Janus Kinase inhibitor baricitinib: Multi-spectroscopic and molecular simulation …

SL Jiang, ZY Hu, WJ Wang, L Hu, L Li, SB Kou… - International Journal of …, 2023 - Elsevier
Abstract Baricitinib is a Janus Kinase (JAK) inhibitor that is primarily used to treat moderately
to severely active rheumatoid arthritis in adults and has recently been reported for the …

Mechanistic and conformational studies on the interaction of human serum albumin with rhodamine B by NMR, spectroscopic and molecular modeling methods

H Rao, W Qi, R Su, Z He, X Peng - Journal of Molecular Liquids, 2020 - Elsevier
Rhodamine B (RB), an important congeneric form of rhodamine dyes, is widely used as a
colorant and tracing agent, and recent studies have shown that it is potentially harmful to …

Insights on the interaction mechanism of brigatinib to human α-1-acid glycoprotein: Experimental and computational approaches

BL Wang, SB Kou, ZY Lin, JH Shi, YX Liu - International journal of …, 2020 - Elsevier
Brigatinib, a multi-target kinase inhibitor, is primarily used to treat anaplastic lymphoma
kinase (ALK)-positive patients with advanced non-small cell lung cancer (NSCLC) who have …

Insight into the binding behavior of ceritinib on human α-1 acid glycoprotein: Multi-spectroscopic and molecular modeling approaches

BL Wang, SB Kou, ZY Lin, JH Shi - … Acta Part A: Molecular and Biomolecular …, 2020 - Elsevier
Ceritinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor for mainly
treating non-small cell lung cancer (NSCLC). This investigation focused on to clarify in detail …

Albumin binding, antioxidant and antibacterial effects of cerium oxide nanoparticles

SZK Roudbaneh, S Kahbasi, MJ Sohrabi… - Journal of Molecular …, 2019 - Elsevier
Herein, the interaction of CeO 2 NPs with HSA was explored by fluorescence, CD, UV–vis
and molecular docking studies. Afterwards, the antioxidant activity of CeO 2 NPs against H 2 …

Multi-spectroscopic and molecular docking technique study of the azelastine interaction with human serum albumin

FM Almutairi, MR Ajmal, MK Siddiqi, M Amir… - Journal of Molecular …, 2020 - Elsevier
Fluorescence and circular dichroism spectroscopic techniques and molecular docking were
used to study binding of azelastine with human serum albumin (HSA). Time resolve …

Synthesis of two novel pyrazolo [1, 5-a] pyrimidine compounds with antibacterial activity and biophysical insights into their interactions with plasma protein

LL He, Q Qi, X Wang, Y Li, Y Zhu, XF Wang, L Xu - Bioorganic Chemistry, 2020 - Elsevier
Two novel water-soluble pyrazolo [1, 5-a] pyrimidine derivatives, 5-chloro-7-(4-methyl-
piperazin− 1-yl)-pyrazolo [1, 5-a] pyrimidine (CMPS) and N′-(5-chloro-pyrazolo [1, 5-a] …

Exploring the interaction of synthesized nickel oxide nanoparticles through hydrothermal method with hemoglobin and lymphocytes: Bio-thermodynamic and cellular …

MZ Nakhjiri, S Asadi, A Hasan, MMN Babadaei… - Journal of Molecular …, 2020 - Elsevier
Abstract The NiO NPs were synthesized by hydrothermal method and their interaction with
Hb was investigated by employing fluorescence, UV–vis absorption techniques as well as …

Millimolar concentration of sodium dodecyl sulfate inhibit thermal aggregation in hen egg white lysozyme via increased α-helicity

JM Khan, A Ahmed, SF Alamery, MA Farah… - Colloids and Surfaces A …, 2019 - Elsevier
The objective of this study was to assess the effects of sodium dodecyl sulphate (SDS) on
the hen egg white lysozyme (HEWL) at pH 9.0. We employed several spectroscopic (light …

[HTML][HTML] Interaction of antitubercular drug candidates with α1-acid glycoprotein produced in pulmonary granulomas

F Zsila, S Bősze, T Beke-Somfai - International journal of biological …, 2020 - Elsevier
The intracellular pathogen Mycobacterium tuberculosis can survive and replicate within host
macrophages. Among various immunomodulatory substances, macrophages also produce …