With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

We describe two structures of the intact bacterial ribosome from Escherichia coli determined
to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed …

▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

Affinity selection-mass spectrometry (AS-MS) is a high-throughput screening (HTS)
technique for drug discovery that enables rapid screening of large collections of compounds …

The faithful and rapid translation of genetic information into peptide sequences is an
indispensable property of the ribosome. The mechanistic understanding of strategies used …

At termination of protein synthesis, type I release factors promote hydrolysis of the peptidyl-
transfer RNA linkage in response to recognition of a stop codon. Here we describe the …

Peptide bond formation and peptide release are catalyzed in the active site of the large
subunit of the ribosome where universally conserved nucleotides surround the CCA ends of …

The termination of protein synthesis occurs through the specific recognition of a stop codon
in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of …