The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Mouse strains are frequently used to model human disease states, to test the efficiency of
drugs and therapeutic principles. However, the direct translation of murine experimental …

Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …

Purpose: Esophageal cancer is an aggressive malignancy and often resistant to therapy.
Overexpression of EGFR has been associated with poor prognosis of patients with …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with a high
mortality rate. Genetic and biochemical studies have shown that RAS signaling mediated by …

Most cells in the liver are polyploid, but the functional role of polyploidy is unknown.
Polyploidization occurs through cytokinesis failure and endoreduplication around the time of …

BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer
(TNBC), which is a refractory disease due to its non-responsiveness to current clinical …

To provide a more comprehensive understanding of the genes and evolutionary forces
driving colorectal cancer (CRC) progression, we performed Sleeping Beauty (SB) …

As the fourth leading cause of cancer-related death in the world, liver cancer poses a major
threat to human health. Although a growing number of therapies have been approved for the …